My diverse interests have resulted in the pursuit of two projects that focus on different aspects of cancer cell biology. In the first of these we are investigating the role that bile acids may have in promoting colon cancer. Here we are investigating the effects that bile acids have on colon cancer etiology using both molecular and cellular biology approaches and animal models to identify bile acid-activated signaling pathways. The second project focuses on a novel observation made while characterizing the interaction between the p53 tumor suppressor and the scaffolding protein 14-3-3 gamma which suggests that 14-3-3 gamma overexpression may cooperate with loss of p53 function to promote chromosome instability. In these studies we are focused on understanding how 14-3-3gamma affects the processes of chromosome segregation.