Our laboratory investigates signal transduction pathways. We are broadly interested in the functional characterization of signal transduction pathways during development and in diseases.
Polarity signaling pathway: We are interested in the signal transduction pathways that regulate cell polarity. Polarity or asymmetry of protein distribution within cells is a fundamental biological property. Many aspects of cell biology such as, asymmetric stem cell division and differentiation, and directional cell migration rely on proper polarity signaling. Our research has characterized the function of a protein kinase – atypical Protein Kinase C or aPKC – in cell adhesion and apical-basal polarity in neural stem/progenitor cells during development . Current research is focused on the comprehensive understanding of the role of aPKC signaling during organogenesis, and its altered function in tumorigenesis and invasion.
TAM family of receptor tyrosine kinases: A tightly regulated inflammatory response is essential for the protection against pathogens. Notwithstanding, unchecked or overzealous inflammation can favor the development of chronic inflammatory and autoimmune diseases. Chronic inflammation, such as in Inflammatory Bowel Disease (IBD), increases the risk of cancer. Our laboratory is investigating TAM signaling components in inflammatory diseases .